主动脉瓣疾病患者心内膜心肌活检中纤维化的相关性
Correlations of fibrosis in endomyocardial biopsies from patients with aortic valve disease.
作者信息
Oldershaw P J, Brooksby I A, Davies M J, Coltart D J, Jenkins B S, Webb-Peploe M M
出版信息
Br Heart J. 1980 Dec;44(6):609-11. doi: 10.1136/hrt.44.6.609.
Abstract
The amount of fibrosis in endomyocardial biopsies from 55 patients with aortic stenosis and 42 patients with aortic regurgitaion was measured. Sixty per cent of the patients with aortic stenosis had some degree of fibrosis; the degree of fibrosis correlated strongly with ejection fraction, peak systolic gradient, symptoms of cardiac failure, and mortality. In patients with aortic regurgitation, fibrosis was found in 40 per cent and was never severe. A correlation was found with symptoms of cardiac failure and mortality at follow-up, but not with ejection fraction or degree of regurgitation.
摘要
对55例主动脉瓣狭窄患者和42例主动脉瓣关闭不全患者的心内膜心肌活检标本中的纤维化程度进行了测量。60%的主动脉瓣狭窄患者存在一定程度的纤维化；纤维化程度与射血分数、收缩期峰值梯度、心力衰竭症状及死亡率密切相关。在主动脉瓣关闭不全患者中，40%发现有纤维化，且均不严重。随访发现其与心力衰竭症状及死亡率相关，但与射血分数或反流程度无关。
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