自发起源的大鼠白血病（SAL）的免疫原性。
Immunogenicity of a rat leukaemia of spontaneous origin (SAL).
作者信息
Wrathmell A B, Alexander P
出版信息
Br J Cancer. 1976 Feb;33(2):181-6. doi: 10.1038/bjc.1976.23.
The SAL rat leukaemia, which resembles acute myeloblastic leukaemia, appeared initially to be non-immunogenic since resistance to an i.p. challenge with as few as 100 cells could not be obtained using stimulation of the RES or by immunization with SAL cells exposed to x-rays, nitrogen mustard, iodoacetate or glutaraldehyde. However, immunization with SAL cells exposed to low doses of mitomycin-C slowed the growth of the challenge inoculum. Cells treated with high doses of mitomycin-C did not immunize. The results are interpreted in terms of rapid shedding of a tumour-specific antigen from the membrane of SAL cells.
SAL大鼠白血病类似于急性髓细胞性白血病，最初似乎是非免疫原性的，因为无论是通过刺激网状内皮系统（RES），还是用经X射线、氮芥、碘乙酸或戊二醛处理的SAL细胞进行免疫，都无法获得对低至100个细胞的腹腔注射攻击的抵抗力。然而，用低剂量丝裂霉素-C处理的SAL细胞进行免疫可减缓攻击接种物的生长。用高剂量丝裂霉素-C处理的细胞则不能产生免疫。这些结果可根据肿瘤特异性抗原从SAL细胞膜上的快速脱落来解释。
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