Li F P, Corkery J, Canellos G, Neitlich H W
Cancer. 1981 Jan 1;47(1):200-2. doi: 10.1002/1097-0142(19810101)47:1<200::aid-cncr2820470132>3.0.co;2-x.
Two sisters had breast cancer at four years and 11 years after diagnosis of Hodgkin's disease. The affected breast tissues had received several hundred rads of scatter radiation during treatment of the lymphoma. Family history revealed breast cancer in a third sister and five other women in the paternal line. Cytogenetic and HLA studies showed no markers of susceptibility to neoplasia. Development of second primary neoplasms of the breast in the two sisters may have resulted from interactions between genetic factors and carcinogenic effects of radiation exposure.
两姐妹在被诊断为霍奇金病后的四年和十一年时患了乳腺癌。在淋巴瘤治疗期间，受影响的乳腺组织接受了数百拉德的散射辐射。家族病史显示，在父系家族中，第三个姐妹和其他五名女性患有乳腺癌。细胞遗传学和HLA研究未发现肿瘤易感性标志物。两姐妹发生乳腺第二原发性肿瘤可能是遗传因素与辐射致癌作用相互作用的结果。
