Lee M Y, Sperlin A, Dale D C
Exp Hematol. 1980 Mar;8(3):249-55.
The skeletal distribution of granulocytopoietic committed stem cells (CFUc) was studied in mice bearing a granulocytosis inducing tumor. The total number of CFUc per mouse was estimated and compared with control mice. In both the axial skeleton (vertebrae, skull, tail) and new areas of marrow development in the peripheral skeleton (radii and ulnae), there was an increased incidence of CFUc, while central appendicular long bones (humeri, femora and tibias) CFUc were unchanged. The study indicated that the total number of CFUc in tumor bearing mice increased, additional data supporting the previous observation and the granulocytosis in this animal model is due to an increase in cell production. The study also indicated that inferences about total CFUc numbers of granulocyte production based on CFUc assay from a single long bone should be interpreted with caution.
对患有粒细胞增多症诱导肿瘤的小鼠中粒细胞生成定向干细胞（CFUc）的骨骼分布进行了研究。估算了每只小鼠CFUc的总数，并与对照小鼠进行了比较。在中轴骨骼（椎骨、颅骨、尾巴）以及外周骨骼中骨髓发育的新区域（桡骨和尺骨），CFUc的发生率均有所增加，而四肢中部的长骨（肱骨、股骨和胫骨）中的CFUc则没有变化。该研究表明，荷瘤小鼠中CFUc的总数增加，这一额外数据支持了先前的观察结果，并且该动物模型中的粒细胞增多症是由于细胞生成增加所致。该研究还表明，基于从单一长骨进行CFUc测定得出的粒细胞生成的总CFUc数量的推断应谨慎解读。
