Teramoto T, Parks A G, Swash M
Gut. 1981 Jan;22(1):45-8. doi: 10.1136/gut.22.1.45.
Biopsies of the external and sphincter taken from 24 male patients with haemorrhoids were subjected to examination using histochemical techniques. Fibre size (type 1 mean: 33 micrometers +/- 11.0 SD and type 2 mean: 47.9 micrometers +/- 15.0 SD) was increased when compared with control subjects. The distribution of muscle fibre types in these patients showed markedly greater type 1 fibre predominance (92%) than in control subjects. These abnormalities of the external sphincter did not show any clear relationship with age, degree of haemorrhoidal change, length of history of haemorrhoids, history of straining or of constipation, or perineal descent; however, increasing length of history up to 10 years was associated with increasing type 1 fibre predominance. We suggest that the external and sphincter in patients with haemorrhoids is in a state of increase tonic contraction, which causes work induced muscle hypertrophy and may contribute to increased resting pressure in the anal canal in patients with haemorrhoids.
对24名患有痔疮的男性患者的外括约肌进行活检，并采用组织化学技术进行检查。与对照组相比，纤维大小（1型平均：33微米±11.0标准差，2型平均：47.9微米±15.0标准差）增加。这些患者的肌纤维类型分布显示，1型纤维优势（92%）明显高于对照组。外括约肌的这些异常与年龄、痔疮变化程度、痔疮病史长短、用力排便或便秘史、或会阴下降均无明显关系；然而，病史长达10年时，1型纤维优势增加。我们认为，痔疮患者的外括约肌处于紧张性收缩增强的状态，这会导致工作诱导性肌肉肥大，并可能导致痔疮患者肛管静息压力增加。
