Holme G, Piechuta H
Immunology. 1981 Jan;42(1):19-24.
Sensitized Sprague-Dawley rats developed respiratory impairment after challenge with aerosolized antigen. The response to challenge was heterogeneous. A proportion of each group of rats developed dyspnea and other symptoms similar to asthma; the remainder developed apnea but no other symptoms. Selective breeding from rats which developed dyspnea increased the incidence from 44% in F0 to 55% in F1 and greater than 90% in F2 and F3. Inbreeding also produced a significant increase in the duration of antigen-induced dyspnea. The results from the selective inbreeding suggest antigen-induced dyspnea is controlled genetically, possibly by multiple gene loci. These inbred rats constitute a population which have a predictable response to aerosolized antigen challenge. They should have utility in investigating allergic asthma and evaluating potential new drugs.
致敏的斯普拉格-道利大鼠在接受雾化抗原激发后出现呼吸功能损害。对激发的反应具有异质性。每组大鼠中有一部分出现呼吸困难和其他类似哮喘的症状；其余的则出现呼吸暂停但无其他症状。从出现呼吸困难的大鼠中进行选择性育种，使发病率从F0代的44%增加到F1代的55%，在F2代和F3代中超过90%。近亲繁殖也使抗原诱导的呼吸困难持续时间显著增加。选择性近亲繁殖的结果表明，抗原诱导的呼吸困难受遗传控制，可能由多个基因位点控制。这些近交系大鼠构成了一个对雾化抗原激发有可预测反应的群体。它们在研究过敏性哮喘和评估潜在新药方面应具有实用价值。
