Carswell F, Oliver J
Int Arch Allergy Appl Immunol. 1978;57(4):358-63. doi: 10.1159/000232125.
Rats systemically sensitized to DNP-ovalbumin show a characteristic respiratory response to antigen challenge delivered via the airway. The slowing of expiratory air flow which occurs on aerosol challenge still occurs when the antigen is injected via a tracheostomy but not when it is delivered solely to the upper airways. Disodium cromoglycate administered via the tracheostomy 1 min before intratracheal antigen challenge reduces the respiratory response.
对二硝基苯基卵清蛋白产生全身致敏的大鼠，在通过气道给予抗原攻击时会表现出特征性的呼吸反应。当通过气管造口术注射抗原时，气溶胶攻击时出现的呼气气流减慢仍然会发生，但当抗原仅递送至上部气道时则不会出现。在气管内抗原攻击前1分钟通过气管造口术给予色甘酸二钠可降低呼吸反应。
