Effects of prostaglandins F2 alpha and E2 on the contractility of non-pregnant human fallopian tube in vitro.

The effects of PGF2 alpha and PGE2 on the distal part of the isolated non-pregnant human fallopian tubes obtained from known menstrual phases has been investigated. Both PGF2 alpha and PGE2 produced an increased contractility of fallopian tube. However, PGF2 alpha was found to be more potent than PGE2 and also the contractions produced by the former compound showed wave forms of relatively high amplitude and low in frequency than that produced by the latter compound. These two compounds did not show a priming effect on each other. There was no discernible effect of phase of the menstrual cycle upon the contractile response to PG.