Caschetto S, Lindblom B, Wiqvist N, Wilhelmsson L
Gynecol Obstet Invest. 1979;10(5):212-20. doi: 10.1159/000299965.
Millimeter-wide muscle strips were prepared from the circular and longitudinal musculature of the oviductal ampulla of fertile women. These specimens were mounted in organ baths for isometric recording of contractile activity. The two types of strips exhibited similar rhythmic spontaneous activity which was found to be present in all phases of the menstrual cycle. Prostaglandin E2 (PGE2) caused an inhibition of contractile activity in both the circular and longitudinal layers, whereas PGF2 alpha induced a marked excitatory response in the specimens. Administration of prostacyclin (PGI2) also elicited an excitatory effect although much less pronounced that that of PGF2 alpha. Pretreatment with ETA, a blocker of endogenous prostaglandin synthesis, abolished the spontaneous contractile activity in a concentration-dependent manner. It is concluded that the ampullary portion of the human oviduct possesses pharmacological properties which differ in certain important respects from those of the isthmus. A shift in the tissue levels of endogenous prostaglandin levels may occur in sequence with ovulation and the pattern of the prostaglandins synthesized seems to be appropriate for the contractile function of the various tubal segments during ovum transport in women.
从受孕女性输卵管壶腹部的环形和纵形肌层制备毫米宽的肌条。将这些标本安装在器官浴槽中以等长记录收缩活动。两种类型的肌条表现出相似的节律性自发活动，且在月经周期的所有阶段均存在。前列腺素E2（PGE2）可抑制环形和纵形肌层的收缩活动，而前列腺素F2α（PGF2α）可在标本中诱导明显的兴奋反应。前列环素（PGI2）的给药也引发兴奋作用，尽管其作用远不如PGF2α明显。用内源性前列腺素合成阻滞剂ETA预处理可呈浓度依赖性消除自发收缩活动。得出的结论是，人类输卵管的壶腹部具有药理学特性，在某些重要方面与峡部不同。内源性前列腺素水平的组织水平变化可能与排卵相继发生，并且合成的前列腺素模式似乎适合女性卵子运输过程中各个输卵管节段的收缩功能。
