Morrison J T, Wilson A F, Vaziri N D, Brunsting L, Davis J
Int J Artif Organs. 1980 Sep;3(5):259-62.
In order to better understand changes in lung function before and after dialysis, we studied eight patients with end-stage renal disease undergoing chronic hemodialysis. Pulmonary tissue volume (Vt), pulmonary capillary blood flow (Qc), the diffusion capacity for carbon monoxide (DLCO), arterial blood gases and body weight were measured before and after dialysis. A single breath, constant expiratory flow technique for determination of of DLCO, Qc and Vt was used. DLCO, Qc, arterial carbon dioxide, and body weight were reduced post dialysis (P less than or equal to .01) while Vt failed to change. The alveolar-arterial oxygen difference rose 123 mmHg (P = .01). These results are consistent with pulmonary microembolization during dialysis with deterioration of gas exchange and Qc. These changes appear to occur independent of significant changes in Vt. Possible physiologic mechanisms are discussed.
为了更好地了解透析前后肺功能的变化，我们研究了8例接受慢性血液透析的终末期肾病患者。在透析前后测量了肺组织容积（Vt）、肺毛细血管血流量（Qc）、一氧化碳弥散量（DLCO）、动脉血气和体重。采用单次呼吸、恒定呼气流量技术测定DLCO、Qc和Vt。透析后DLCO、Qc、动脉二氧化碳分压和体重降低（P≤0.01），而Vt未改变。肺泡-动脉血氧分压差升高123 mmHg（P = 0.01）。这些结果与透析期间肺微栓塞伴气体交换和Qc恶化一致。这些变化似乎独立于Vt的显著变化而发生。文中讨论了可能的生理机制。
