双硫仑对二乙基亚硝胺诱导大鼠肝脏DNA烷基化的影响。
Effect of disulfiram on the alkylation of rat liver DNA by nitrosodiethylamine.
作者信息
Frank N, Hadjiolov D, Bertram B, Wiessler M
出版信息
J Cancer Res Clin Oncol. 1980;97(2):209-12. doi: 10.1007/BF00409908.
Abstract
The extent of ethylation of guanine in 7 N and O 6 position in rat liver DNA was studied after chronic feeding with unlabelled nitrosodiethylamine followed by a single application of the 14C labelled drug. Disulfiram inhibits the alkylation of rat liver DNA. It was also shown that a discontinuous dosage of disulfiram protects against the alkylating effect of 14C nitrosodiethylamine only for a distinct period of time.
摘要
在用未标记的二乙基亚硝胺长期喂养大鼠后，再单次给予14C标记的该药物，研究了大鼠肝脏DNA中鸟嘌呤在N7和O6位置的乙基化程度。双硫仑抑制大鼠肝脏DNA的烷基化。还表明，间断给药的双硫仑仅在一段特定时间内对14C二乙基亚硝胺的烷基化作用具有保护作用。
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