双硫仑对大鼠N-甲基-N-亚硝基苄胺毒性和致癌性的影响（作者译）
[Effect of disulfiram on the toxicity and carcinogenicity of N-methyl-n-nitrosobenzylamine in rats (author's transl)].
作者信息
Schweinsberg F, Bürkle V
出版信息
J Cancer Res Clin Oncol. 1981;102(1):43-7. doi: 10.1007/BF00410533.
Abstract
The concurrent application of disulfiram (710 mg/kg diet; or 200 mg/kg diet) effects a strong enhancement of the toxicity and an acceleration of the formation of esophageal tumors by N-methyl-N-nitrosobenzylamine (10 mg/l drinking water) in female SIV 50 rats. Besides that squamous cell papilloma in the trachea and extended squamous cell metaplasia in the bronchus system with potentially but not safely precancerous nature were seen.
摘要
在雌性SIV 50大鼠中，同时应用双硫仑（710毫克/千克饮食；或200毫克/千克饮食）可显著增强N-甲基-N-亚硝基苄胺（10毫克/升饮用水）的毒性，并加速食管肿瘤的形成。除此之外，还观察到气管中的鳞状细胞乳头瘤以及支气管系统中广泛的鳞状细胞化生，具有潜在但并非绝对的癌前性质。
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本文引用的文献
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Carcinogenesis. 1980;1(10):861-6. doi: 10.1093/carcin/1.10.861.
2
Effect of disulfiram on the alkylation of rat liver DNA by nitrosodiethylamine.双硫仑对二乙基亚硝胺诱导大鼠肝脏DNA烷基化的影响。
J Cancer Res Clin Oncol. 1980;97(2):209-12. doi: 10.1007/BF00409908.
3
[Organotropic carcinogenic effects of 65 various N-nitroso- compounds on BD rats].[65种不同N-亚硝基化合物对BD大鼠的器官特异性致癌作用]
Z Krebsforsch. 1967;69(2):103-201.
4
Inhibition of macromolecular binding of benzo(a)pyrene and inhibition of neoplasia by disulfiram in the mouse forestomach.双硫仑对小鼠前胃中苯并(a)芘大分子结合的抑制作用及对肿瘤形成的抑制作用。
J Natl Cancer Inst. 1976 Jul;57(1):173-9. doi: 10.1093/jnci/57.1.173.
5
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Biochem Pharmacol. 1977 Oct 1;26(19):1763-8. doi: 10.1016/0006-2952(77)90343-4.
6
7
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8
9
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