Puck J M, Glezen W P, Frank A L, Six H R
J Infect Dis. 1980 Dec;142(6):844-9. doi: 10.1093/infdis/142.6.844.
Transplacentally acquired antibody to influenza A virus was measured by a microneutralization test and a radioimmunoprecipitation assay in cord blood obtained from infants at a large urban county hospital in 1975-1978. Random samples tested before epidemic periods were a measure of susceptibility of the population. Twenty-six infants from whom cord sera were available had culture-documented infections with influenza A/Victoria (H3N2) virus when younger than four months. The direct correlation between age at the time of infection and level of antibody measured in cord serum (P less than 0.002) suggested a protective effect of transplacentally acquired antibody. None of fourteen acute-phase serum specimens obtained early in the course of culture-positive infections of young infants had detectable antibody to influenza A viral hemagglutinin by the sensitive radioimmunoprecipitation test. Because passively transferred maternal antibody to influenza virus may prevent symptomatic infection in young infants, vaccination of pregnant women could be beneficial.
1975年至1978年期间，在一家大型城市县医院采集的婴儿脐带血中，通过微量中和试验和放射免疫沉淀试验检测了经胎盘获得的甲型流感病毒抗体。在流行期之前检测的随机样本是衡量人群易感性的指标。26名有脐带血清的婴儿在4个月龄之前有甲型/维多利亚（H3N2）病毒感染的培养记录。感染时的年龄与脐带血清中检测到的抗体水平之间的直接相关性（P小于0.002）表明经胎盘获得的抗体具有保护作用。在幼儿培养阳性感染过程早期获得的14份急性期血清标本中，通过灵敏的放射免疫沉淀试验均未检测到针对甲型流感病毒血凝素的抗体。由于母体被动转移的流感病毒抗体可能预防幼儿出现症状性感染，因此孕妇接种疫苗可能有益。
