Parkey R W, Kulkarni P V, Lewis S E, Datz F L, Dehmer G J, Gutekunst D P, Buja L M, Bonte F J, Willerson J T
J Nucl Med. 1981 Feb;22(2):133-7.
The effect of blood flow and site of injection on Tc-99m PPi uptake in acute myocardial infarction was studied in a group of 24 dogs. Temporary (3 hr) and permanent LAO occlusion models were used. Animals with the temporary occlusions showed scintigraphic visualization of the infarcts and reversal of the normal epito-endocardial Tc-99m PPi ratio in contrast to those with permanent coronary occlusions. The data demonstrate that early (within 3 hr) experimental canine myocardial infarcts can be detected with Tc-99m PPi if reflow to the area of infarction is provided. Delayed development of abnormal Tc-99m PPi scintigrams with acute infarction is related primarily to the initial lack of adequate blood flow to the damaged tissue, with subsequent development of adequate collateral flow allowing delivery and uptake of sufficient amount of the radiopharmaceutical for in vivo scintigraphic detection of the damaged area(s).
在一组24只犬中研究了血流和注射部位对急性心肌梗死时锝-99m焦磷酸钠（Tc-99m PPi）摄取的影响。采用了临时（3小时）和永久性左前降支闭塞模型。与永久性冠状动脉闭塞的动物相比，临时闭塞的动物梗死灶有闪烁显像可见，且正常的心外膜-心内膜Tc-99m PPi比值发生逆转。数据表明，如果梗死区域有再灌注，早期（3小时内）实验性犬心肌梗死可用Tc-99m PPi检测到。急性梗死时Tc-99m PPi闪烁图异常的延迟出现主要与受损组织最初缺乏足够血流有关，随后足够的侧支血流发展，使足够量的放射性药物得以输送和摄取，从而在体内对受损区域进行闪烁显像检测。
