Kulkarni P V, Parkey R W, Wilson J E, Lewis S E, Buja L M, Bonte F J, Willerson J T
J Nucl Med. 1980 Feb;21(2):117-21.
We have reported previously that technetium-99m heparin (TcH) accumulates in, and allows scintigraphic identification of, damaged canine myocardium occurring with temporary occlusion and reperfusion of the left anterior descending (LAD) coronary artery. A recent modification consists of using heparin from sheep lung, with stannous phosphate as the reducing agent. In 12 dogs with permanent LAD occlusion, six were injected intravenously with TcH (3--6 mCi) at 24 hr after occlusion, and six at 48 hr. Each experimental animal demonstrated relatively high TcH uptake in the left-ventircular infarct region as compared with normal myocardium. The in vivo scintigrams in all animals with gross myocardial infarcts were positive. The results suggest that this modified TcH has value for identifying experimental myocardial infarcts and that the reduced bone uptake, compared with that occurring with Tc-99m phosphates, may be an advantage for scintigraphic infarct detection.
我们之前曾报道，锝-99m肝素（TcH）会在因左前降支（LAD）冠状动脉暂时闭塞和再灌注而受损的犬类心肌中蓄积，并能通过闪烁显像进行识别。最近的一项改进是使用来自羊肺的肝素，以磷酸亚锡作为还原剂。在12只LAD永久性闭塞的犬中，6只在闭塞后24小时静脉注射TcH（3 - 6毫居里），6只在48小时注射。与正常心肌相比，每只实验动物的左心室梗死区域均显示出相对较高的TcH摄取。所有有明显心肌梗死的动物体内闪烁图均为阳性。结果表明，这种改良的TcH对于识别实验性心肌梗死具有价值，并且与99m锝磷酸盐相比，骨摄取减少可能是闪烁显像检测梗死的一个优势。
