Dobiásová M, Vondra K
Scand J Clin Lab Invest Suppl. 1978;150:129-33. doi: 10.3109/00365517809104913.
Basal values of lecithin:cholesterol acyltransferase (LCAT) were estimated in healthy subjects, in patients with the so-called risk ischemic heart diseases (IHD)--obesity, diabetes, hypertension, and hyperlipoproteinemia II--and in patients with a IHD-infarction of the myocardium. A precise method employing a 14C-4-cholesterol-labeled common normolipidemic substrate was used. A highly significant difference in the average values of LCAT activity between healthy men and women was found. LCAT in men with 'risk' diseases decreased, while in women it remained at the level of the reference group. To assess the dependence between LCAT-dependent indicators and IHD, criteria for evaluating the deviations from reference values were proposed. The number of deviations from the reference group increased in the sequence: obesity, hypertension, diabetes, hyperlipoproteinemia, and the infarction of the myocardium.
在健康受试者、患有所谓缺血性心脏病（IHD）风险疾病（肥胖症、糖尿病、高血压和II型高脂蛋白血症）的患者以及患有IHD心肌梗死的患者中，对卵磷脂：胆固醇酰基转移酶（LCAT）的基础值进行了评估。采用了一种精确的方法，使用14C-4-胆固醇标记的普通正常血脂底物。发现健康男性和女性的LCAT活性平均值存在高度显著差异。患有“风险”疾病的男性的LCAT降低，而女性的LCAT则保持在参考组水平。为了评估LCAT相关指标与IHD之间的相关性，提出了评估与参考值偏差的标准。与参考组的偏差数量按以下顺序增加：肥胖症、高血压、糖尿病、高脂蛋白血症和心肌梗死。
