Cucuianu M, Opincaru A, Tapalagă D
Clin Chim Acta. 1978 Apr 3;85(1):73-9. doi: 10.1016/0009-8981(78)90103-1.
Using exogenous substrate for its assay, lecithin:cholesterol acyltransferase (LCAT) was found to be decreased in liver disease and higher than normal in endogenous hypertriglyceridemia. LCAT activity was positively correlated with serum cholesterol and triglyceride. However in the six patients with excessive hypertriglyceridemia (type V), LCAT activity was lower than in type IV hyperlipoproteinemia. LCAT activity was not changed significantly in type II-a hyperlipoproteinemia. A striking parallel was noted between plasma LCAT and serum pseudocholinesterase activity. It suggested that both these liver secretion enzymes might be induced by an accelerated turnover of serum lipids and lipoproteins. Pathogenical implications of these findings are briefly discussed.
利用外源性底物对卵磷脂胆固醇酰基转移酶（LCAT）进行测定时，发现其在肝脏疾病中降低，而在内源性高甘油三酯血症中高于正常水平。LCAT活性与血清胆固醇和甘油三酯呈正相关。然而，在6例严重高甘油三酯血症（V型）患者中，LCAT活性低于IV型高脂蛋白血症患者。II-a型高脂蛋白血症患者的LCAT活性无明显变化。血浆LCAT与血清假性胆碱酯酶活性之间存在显著平行关系。这表明这两种肝脏分泌酶可能是由血清脂质和脂蛋白周转加快所诱导。简要讨论了这些发现的病理学意义。
