Dousset N, Dousset J C, Soula G, Douste-Blazy L
Scand J Clin Lab Invest Suppl. 1978;150:21-5. doi: 10.3109/00365517809104895.
The effect of dicarboxylic lecithins on the lecithin:cholesterol acyltransferase [LCAT] activity was studied with a partially purified preparation [approximately 24-fold]. The presence of dicarboxylic lecithins is followed by the inhibition of LCAT. The inhibition is proportional to the concentration of glutaryl-lecithin and is about 50% with 0.16 mM glutaryl-lecithin. For a higher concentration, the inhibition is total. The inhibition of LCAT activity was of a mixed type. It can be explained by a combination of competitive inhibition and interaction of glutaryl-lecithin with phospholipid, which changes the physical properties of lipid, making it less available for conversion into cholesteryl ester.
用部分纯化制剂（约24倍）研究了二羧酸卵磷脂对卵磷脂胆固醇酰基转移酶（LCAT）活性的影响。二羧酸卵磷脂的存在会导致LCAT受到抑制。这种抑制与戊二酰卵磷脂的浓度成正比，在0.16 mM戊二酰卵磷脂时约为50%。对于更高的浓度，抑制是完全的。LCAT活性的抑制属于混合型。这可以通过竞争性抑制以及戊二酰卵磷脂与磷脂的相互作用来解释，这种相互作用改变了脂质的物理性质，使其转化为胆固醇酯的可用性降低。
