Brown S A, Hutchinson R, Morrisett J, Boerwinkle E, Davis C E, Gotto A M, Patsch W
Department of Medicine, Duke University Medical Center, Durham, NC 27710.
Arterioscler Thromb. 1993 Aug;13(8):1139-58. doi: 10.1161/01.atv.13.8.1139.
The distributions of plasma lipids, lipoproteins, and apoproteins of 14,524 female and male black and white participants 45 to 64 years old in the Atherosclerosis Risk in Communities (ARIC) Study are presented. All specimens were analyzed at a central laboratory. Mean total cholesterol levels increased with increasing age across all ages from 204 to 229 mg/dL (12%) in women and from 208 to 213 mg/dL (2%) in men. Triglyceride levels increased with age in women, remained stable in men, and were higher in whites than blacks. High-density lipoprotein (HDL) cholesterol levels were higher in black and white women (range, 57 to 59 mg/dL) compared with black men (49 to 52 mg/dL) or white men (42 to 43 mg/dL). Cholesterol associated with HDL was distributed in a relatively constant proportion between HDL3 (70% to 76%) and HDL2 (24% to 30%) for all race/sex groups. Low-density lipoprotein (LDL) cholesterol levels increased with age in black (14.7%) and white (17.1%) women and in black (4.4%) and white (3.7%) men; more than 50% of all participants had LDL cholesterol levels > 130 mg/dL. Apoprotein A-I and B levels followed the same trends as HDL cholesterol and LDL cholesterol levels, respectively. Lipoprotein(a) [Lp(a)] levels were twice as high in blacks as in whites, and women's Lp(a) levels were higher than men's Lp(a) levels for each race. Menopause was associated with elevated total cholesterol, LDL cholesterol, apoprotein B, and Lp(a) levels, and hormone replacement medication use in postmenopausal subjects was associated with higher HDL cholesterol, triglyceride, and apoprotein A-I levels and lower LDL cholesterol, apoprotein B, and Lp(a) levels.
本文呈现了社区动脉粥样硬化风险（ARIC）研究中14524名45至64岁的黑人和白人女性及男性参与者的血浆脂质、脂蛋白和载脂蛋白分布情况。所有样本均在中心实验室进行分析。女性的平均总胆固醇水平随年龄增长而升高，在所有年龄段中从204毫克/分升降至229毫克/分升（12%），男性则从208毫克/分升降至213毫克/分升（2%）。甘油三酯水平在女性中随年龄增长而升高，在男性中保持稳定，且白人高于黑人。与黑人男性（49至52毫克/分升）或白人男性（42至43毫克/分升）相比，黑人和白人女性的高密度脂蛋白（HDL）胆固醇水平更高（范围为57至59毫克/分升）。对于所有种族/性别组，与HDL相关的胆固醇在HDL3（70%至76%）和HDL2（24%至30%）之间以相对恒定的比例分布。黑人（14.7%）和白人（17.1%）女性以及黑人（4.4%）和白人（3.7%）男性的低密度脂蛋白（LDL）胆固醇水平随年龄增长而升高；超过50%的参与者LDL胆固醇水平>130毫克/分升。载脂蛋白A-I和B水平分别与HDL胆固醇和LDL胆固醇水平呈现相同趋势。黑人的脂蛋白(a) [Lp(a)]水平是白人的两倍，且在每个种族中女性的Lp(a)水平均高于男性。绝经与总胆固醇、LDL胆固醇、载脂蛋白B和Lp(a)水平升高相关，绝经后受试者使用激素替代药物与较高的HDL胆固醇、甘油三酯和载脂蛋白A-I水平以及较低的LDL胆固醇、载脂蛋白B和Lp(a)水平相关。
