Strauss M, Sharkey F E
Laryngoscope. 1981 Mar;91(3):432-8. doi: 10.1288/00005537-198103000-00014.
The phenomenon of multiple primary malignant neoplasms involving the head and neck is well documented. Epidermoid carcinomas constitute the majority of these neoplasms. Case reports are made of two patients with simultaneously occurring chronic reticuloendothelial malignancies and non-epidermoid tumors involving the head and neck. The first case is one of chronic lymphocytic leukemia (CLL) and metastatic primary retroperitoneal extragonadal seminoma, while the second is one of lymphocytic lymphoma (LL) and a carotid body tumor (CBT). The head and neck manifestations of metastatic seminoma, CBT, and CLL and LL are discussed. A review of the literature of the association of each of these entities to other tumors is presented. Also presented is the evidence for an increased incidence of malignancies associated with CLL and LL and the complicating factors introduced when reticuloendothelial malignancies occur simultaneously with head and neck neoplasms.
头颈部出现多个原发性恶性肿瘤的现象已有充分记载。表皮样癌构成了这些肿瘤的大多数。现报告两例同时发生慢性网状内皮系统恶性肿瘤和涉及头颈部的非表皮样肿瘤的患者。第一例是慢性淋巴细胞白血病（CLL）和转移性原发性腹膜后性腺外精原细胞瘤，第二例是淋巴细胞淋巴瘤（LL）和颈动脉体瘤（CBT）。文中讨论了转移性精原细胞瘤、CBT以及CLL和LL的头颈部表现。还综述了这些疾病中每种疾病与其他肿瘤关联的文献。此外，还介绍了与CLL和LL相关的恶性肿瘤发病率增加的证据，以及网状内皮系统恶性肿瘤与头颈部肿瘤同时发生时出现的复杂因素。
