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1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, a potent phenobarbital-like inducer of microsomal monooxygenase activity.

作者信息

Poland A, Mak I, Glover E, Boatman R J, Ebetino F H, Kende A S

出版信息

Mol Pharmacol. 1980 Nov;18(3):571-80.

PMID:7464820
Abstract
摘要

相似文献

1
1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, a potent phenobarbital-like inducer of microsomal monooxygenase activity.1,4-双[2-(3,5-二氯吡啶氧基)]苯，一种强效的类似苯巴比妥的微粒体单加氧酶活性诱导剂。
Mol Pharmacol. 1980 Nov;18(3):571-80.
2
Species differences in responsiveness to 1,4-bis[2-(3,5-dichloropyridyloxy)]-benzene, a potent phenobarbital-like inducer of microsomal monooxygenase activity.对1,4-双[2-(3,5-二氯吡啶氧基)]苯（一种强力的类似苯巴比妥的微粒体单加氧酶活性诱导剂）反应性的种属差异。
Mol Pharmacol. 1981 Sep;20(2):442-50.
3
[Comparison of the inducing effect of triphenyldioxan, bis-(dichloropyridyloxy)benzene and phenobarbital on the liver monooxygenase].三苯二氧烷、双（二氯吡啶氧基）苯和苯巴比妥对肝脏单加氧酶诱导作用的比较
Biokhimiia. 1990 Jan;55(1):29-36.
4
Long-term induction of microsomal drug oxidizing system in mice following prenatal exposure to barbiturate.小鼠产前暴露于巴比妥酸盐后微粒体药物氧化系统的长期诱导。
Biochem Pharmacol. 1979 Apr 15;28(8):1429-30. doi: 10.1016/0006-2952(79)90448-9.
5
Effects of lipid ingestion on the induction of drug metabolizing enzymes of nuclear envelope and microsomes by phenobarbital.脂质摄入对苯巴比妥诱导核膜和微粒体药物代谢酶的影响。
J Environ Pathol Toxicol. 1980 Aug;4(1):219-35.
6
1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) and related compounds as inducers of hepatic monooxygenases. Structure-activity effects.1,4-双[2-(3,5-二氯吡啶氧基)]苯（TCPOBOP）及相关化合物作为肝单加氧酶诱导剂。构效关系。
Biochem Pharmacol. 1985 Oct 1;34(19):3489-94. doi: 10.1016/0006-2952(85)90722-1.
7
Impact of neonatal benzpyrene imprinting on liver microsomal enzyme induction by benzpyrene and phenobarbital in adulthood.新生儿苯并芘印记对成年期苯并芘和苯巴比妥诱导肝微粒体酶的影响。
Acta Physiol Hung. 1991;78(2):151-5.
8
Mouse hepatic cytochrome P-450 isozyme induction by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, pyrazole, and phenobarbital.1,4-双[2-(3,5-二氯吡啶氧基)]苯、吡唑和苯巴比妥对小鼠肝脏细胞色素P-450同工酶的诱导作用。
Biochem Pharmacol. 1988 Nov 1;37(21):4141-7. doi: 10.1016/0006-2952(88)90108-6.
9
Phenobarbital liver microsomal induction in MHV-3 viral hepatitis of the mouse.
Experientia. 1972 Sep 15;28(9):1011-2. doi: 10.1007/BF01918642.
10
Influence of mixed-function oxidase inducers on the in vitro metabolism of N'-nitrosonornicotine by rat and hamster liver microsomes.混合功能氧化酶诱导剂对大鼠和仓鼠肝微粒体体外代谢N'-亚硝基去甲烟碱的影响。
Drug Metab Dispos. 1981 Mar-Apr;9(2):168-9.

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Steatotic liver disease induced by TCPOBOP-activated hepatic constitutive androstane receptor: primary and secondary gene responses with links to disease progression.TCPOBOP 激活的肝组成型雄烷受体诱导的脂肪变性肝病：与疾病进展相关的原发性和继发性基因反应。
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Negative Regulation of Human Hepatic Constitutive Androstane Receptor by Cholesterol Synthesis Inhibition: Role of Sterol Regulatory Element Binding Proteins.
胆固醇合成抑制对人肝组成型雄烷受体的负调控：固醇调节元件结合蛋白的作用。
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Human constitutive androstane receptor agonist DL5016: A novel sensitizer for cyclophosphamide-based chemotherapies.人源组成型雄烷受体激动剂 DL5016：一种新型增敏剂，可增强基于环磷酰胺的化疗药物疗效。
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The gene expression profile of a drug metabolism system and signal transduction pathways in the liver of mice treated with tert-butylhydroquinone or 3-(3'-tert-butyl-4'-hydroxyphenyl)propylthiosulfonate of sodium.用叔丁基对苯二酚或3-(3'-叔丁基-4'-羟基苯基)丙基硫代磺酸钠处理的小鼠肝脏中药物代谢系统和信号转导通路的基因表达谱
PLoS One. 2017 May 3;12(5):e0176939. doi: 10.1371/journal.pone.0176939. eCollection 2017.
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Bioinformatic analysis of microRNA networks following the activation of the constitutive androstane receptor (CAR) in mouse liver.小鼠肝脏中组成型雄烷受体（CAR）激活后microRNA网络的生物信息学分析
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Activation of Constitutive Androstane Receptor (CAR) in Mice Results in Maintained Biliary Excretion of Bile Acids Despite a Marked Decrease of Bile Acids in Liver.在小鼠中，组成型雄烷受体（CAR）的激活导致尽管肝脏中胆汁酸显著减少，但胆汁酸的胆汁排泄仍得以维持。
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A targeted in vivo SILAC approach for quantification of drug metabolism enzymes: regulation by the constitutive androstane receptor.一种用于定量药物代谢酶的靶向体内稳定同位素标记氨基酸法：组成型雄烷受体的调控作用
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Clin Pharmacokinet. 2003;42(15):1331-57. doi: 10.2165/00003088-200342150-00003.