Tovey E R, Chapman M D, Platts-Mills T A
Nature. 1981 Feb 12;289(5798):592-3. doi: 10.1038/289592a0.
The association between house dust allergy and asthma has long been recognized, and it has been demonstrated that a major allergen in house dust is related to the presence of mites of the genus Dermatophagoides. Using extracts of mite culture for skin testing, as many as 10% of the population and up to 90% of allergic asthmatics give positive immediate reactions. Although mites may occasionally become airborne during bed-making, it has also been demonstrated that they 'secrete or excrete' some allergen. Recently, we have shown that up to three-quarters of the serum IgE antibodies to mites are directed against a major allergen-antigen P1 (molecular weight 24,000). Using a radioimmunoassay it is possible to measure the concentration of this glycoprotein in both dust samples and mite cultures. These measurements, which are reported here, show that more than 95% of the allergen accumulating in mite cultures is associated with faecal particles.
屋尘过敏与哮喘之间的关联早已为人所知，并且已经证明屋尘中的一种主要变应原与尘螨属螨虫的存在有关。使用螨培养提取物进行皮肤试验时，多达10%的人群以及高达90%的过敏性哮喘患者会出现阳性即刻反应。尽管螨虫在铺床时偶尔可能会进入空气，但也已证明它们“分泌或排泄”一些变应原。最近，我们发现高达四分之三的针对螨虫的血清IgE抗体是针对一种主要变应原——抗原P1（分子量24,000）的。使用放射免疫测定法可以测量尘样和螨培养物中这种糖蛋白的浓度。此处报告的这些测量结果表明，螨培养物中积累的超过95%的变应原与粪便颗粒有关。
