Whittle M J, Koh K S, Hon E H, Kulovich M, Gluck L
Obstet Gynecol. 1981 Mar;57(3):335-9.
Serial samples of amniotic fluid were taken from 38 patients in spontaneous labor and the lecithin:sphingomyelin (L:S) ratios were estimated. The fetal heart rate (FHR) pattern for each patient was analyzed, and the baseline rate, long-term variability, and periodic changes wee determined. It was found that changes in the L:S ratios were significantly correlated with the duration of labor and FHR long-term variability. Very low L:S ratios were observed in some patients whose infants did not subsequently develop respiratory distress syndrome. This raises the possibility that during labor the amniotic fluid is no longer representative of lung fluid, perhaps because of reduced tracheal fluid efflux, a process which may operate when the fetus is under stress.
从38例自然分娩的患者中采集羊水系列样本，并测定卵磷脂:鞘磷脂（L:S）比值。分析每位患者的胎儿心率（FHR）模式，确定基线率、长期变异性和周期性变化。发现L:S比值的变化与产程和FHR长期变异性显著相关。在一些婴儿随后未发生呼吸窘迫综合征的患者中观察到极低的L:S比值。这增加了一种可能性，即在分娩期间羊水不再代表肺液，可能是由于气管液体流出减少，当胎儿处于应激状态时可能会发生这种情况。
