Baillet J, Paillard J, Behar A, Sainte-Laudy B, Albagli B, Dureuil J
Nouv Presse Med. 1981 Jan 31;10(4):235-7.
Among more than 7000 adult patients with suspected dysthyroidism in who radioimmune assays were performed, the authors have selected 21 patients with high TSH hypothyroidism who had assays before and after replacement therapy with various preparations prescribed by their G.P. The results in this group of 61 treatments of at least 3 weeks duration were as follows: (1) under thyroid extract or thyroglobulin (21 treatments), the condition persisted in the majority of patients; (2) under thyroxine (31 treatments), the thyroid function returned to normal with a once-a-day dose of 150 mcg/-T4; (3) under triiodothyronine (7 treatments), none of the patients reverted to euthyroidism. Levothyroxine therapy therefore appears to be the most effective and cheapest way of providing optimal replacement therapy in patients with hypothyroidism. The daily dose of about 150 mcg can easily be adjusted according to the results of occasional hormonal assays.
在7000多名接受放射免疫测定的疑似甲状腺功能障碍成年患者中,作者挑选出21名促甲状腺激素水平高的甲状腺功能减退患者,这些患者在全科医生开具的各种制剂替代治疗前后均进行了测定。这组至少为期3周的61次治疗结果如下:(1)使用甲状腺提取物或甲状腺球蛋白治疗(21次治疗),大多数患者病情持续存在;(2)使用甲状腺素治疗(31次治疗),每日服用150 mcg / -T4时甲状腺功能恢复正常;(3)使用三碘甲状腺原氨酸治疗(7次治疗),无患者恢复到甲状腺功能正常状态。因此,左甲状腺素治疗似乎是为甲状腺功能减退患者提供最佳替代治疗的最有效且最便宜的方法。约150 mcg的每日剂量可根据偶尔的激素测定结果轻松调整。