Buvat J
Nouv Presse Med. 1980 May 31;9(24):1699-702.
The so-called idiopathic hirsutism almost invariably involves hormonal disorders. Through secretion and peripheral conversion of precursors, there is an increase in androgens (mainly testosterone and androstenedione), often produced by both ovarian and adrenal glands, whilst a diminution of the binding protein leads to an increase in free testosterone. As in male puberty, this process activates a 5 alpha-reductase in the pilosebaceous glands located in areas normally reserved to male hairiness. The enzyme, in turn, transforms testosterone into dihydrotestosterone in situ, and the latter induces and maintains hair growth.
所谓的特发性多毛症几乎总是涉及激素紊乱。通过前体的分泌和外周转化，雄激素（主要是睾酮和雄烯二酮）增加，通常由卵巢和肾上腺共同产生，而结合蛋白减少导致游离睾酮增加。如同男性青春期一样，这一过程激活了位于通常为男性多毛区域的皮脂腺中的5α-还原酶。该酶进而在原位将睾酮转化为二氢睾酮，后者诱导并维持毛发生长。
