Simon T R, Neumann R L, Gorelick F, Riely C, Hoffer P, Goffschalk A
Radiology. 1981 Mar;138(3):723-6. doi: 10.1148/radiology.138.3.7465853.
Receiver operator characteristic (ROC) techniques were used to determine relative importance of heterogeneity, bone marrow uptake, hepatomegaly, splenomegaly, and focal lesions in the scintigraphic diagnosis of cirrhosis, as well as to determine whether each of the criteria should be used as an identifier (high sensitivity) or as a discriminator (high specificity). Heterogeneity, splenomegaly, and bone marrow uptake were found to be good identifiers of hepatic disease. However, heterogeneity was found to be a poor discriminator for cirrhosis, splenomegaly showed some value as a discriminator, and bone marrow uptake was found to be a reliable discriminator for alcoholic liver disease. The presence of focal lesions was a good discriminator for metastatic disease, and was not specific for cirrhosis. Hepatomegaly also was not specific for cirrhosis. This method of analysis provides a relatively simple method for assembling a hierarchical guide to diagnostic criteria for the interpreting physician.
采用接受者操作特征（ROC）技术来确定在肝硬化闪烁显像诊断中，异质性、骨髓摄取、肝肿大、脾肿大及局灶性病变的相对重要性，同时确定每个标准应作为识别指标（高敏感性）还是鉴别指标（高特异性）。结果发现，异质性、脾肿大及骨髓摄取是肝病的良好识别指标。然而，异质性被发现是肝硬化的较差鉴别指标，脾肿大作为鉴别指标有一定价值，而骨髓摄取是酒精性肝病的可靠鉴别指标。局灶性病变的存在是转移性疾病的良好鉴别指标，对肝硬化不具有特异性。肝肿大对肝硬化也不具有特异性。这种分析方法为解读医师提供了一种相对简单的方法，用于构建诊断标准的分层指南。
