杂交瘤抗体与羊水和血浆纤连蛋白的反应性。
Reactivity of hybridoma antibodies with amniotic and plasma fibronectin.
作者信息
Kuusela P, Bång B E, Hurme M, Mäkelä O
出版信息
Scand J Immunol. 1980;12(4):331-7. doi: 10.1111/j.1365-3083.1980.tb00074.x.
Abstract
Mouse antibodies were prepared to human amniotic fluid fibronectin by means of somatic cell hybrids. Comparison of immunological reactivity of antibodies with amniotic and plasma fibronectin revealed that the two molecules had very similar patterns of antigenic determinants. Antibodies from one cell population, however, bound better to amniotic fluid fibronectin, indicating that there is a difference in the molecular structure of fibronectins isolated from the two sources.
摘要
通过体细胞杂交制备了针对人羊水纤连蛋白的小鼠抗体。将这些抗体与羊水纤连蛋白和血浆纤连蛋白的免疫反应性进行比较，结果显示这两种分子具有非常相似的抗原决定簇模式。然而，来自一个细胞群体的抗体与羊水纤连蛋白的结合更好，这表明从这两种来源分离的纤连蛋白在分子结构上存在差异。
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