Tinkanen H, Rorarius M, Metsä-Ketelä T
Department of Obstetrics and Gynaecology, University Hospital of Tampere, Finland.
Gynecol Obstet Invest. 1993;35(1):7-11. doi: 10.1159/000292654.
The concentrations of adrenaline and noradrenaline were determined in venous plasma and cerebrospinal fluid (CSF) of 41 pregnant women at term scheduled for elective or 'hot' caesarean section and in 7 healthy non-pregnant women scheduled for elective surgery. Group 1: 10 pregnant women at term with a normal history of their pregnancy; group 2: like group 1, but in active labour for more than 4 h; group 3: 10 pregnant women with insulin-dependent diabetes mellitus with or without slightly elevated arterial blood pressure; group 4: 11 women with pre-eclampsia gravis; group 5: 7 healthy non-pregnant women of fertile age. The highest values of mean arterial blood pressure and of venous plasma noradrenaline were found in the pre-eclamptic group 4, mean arterial blood pressure and plasma noradrenaline levels correlated to each other. However, concentrations of noradrenaline in CSF in group 4 did not differ significantly from the other groups. It is speculated that a different origin of hypertension may be the reason for the normal noradrenaline concentrations in CSF. This finding is in contrast to earlier findings in which noradrenaline levels in CSF were elevated in patients with essential hypertension.
对41名足月计划进行择期或“紧急”剖宫产的孕妇以及7名计划进行择期手术的健康非孕妇的静脉血浆和脑脊液（CSF）中的肾上腺素和去甲肾上腺素浓度进行了测定。第1组：10名足月且孕期正常的孕妇；第2组：与第1组类似，但处于活跃分娩期超过4小时；第3组：10名患有胰岛素依赖型糖尿病且伴有或不伴有轻度动脉血压升高的孕妇；第4组：11名重度子痫前期妇女；第5组：7名健康的育龄非孕妇。子痫前期第4组的平均动脉血压和静脉血浆去甲肾上腺素值最高，平均动脉血压与血浆去甲肾上腺素水平相互关联。然而，第4组脑脊液中的去甲肾上腺素浓度与其他组相比无显著差异。据推测，高血压的不同起源可能是脑脊液中去甲肾上腺素浓度正常的原因。这一发现与早期研究结果相反，早期研究中，原发性高血压患者脑脊液中的去甲肾上腺素水平升高。
