Christou N V, Meakins J L, MacLean L D
Surg Gynecol Obstet. 1981 Mar;152(3):297-301.
Seven hundred and twenty-seven surgical patients who were skin tested with recall antigens prior to operation were analyzed. The analysis included preoperative diagnosis, operative intervention, postoperative septic complications and death. The normal skin test responders were of similar age and had equal degrees of surgical procedures performed compared with patients who were anergic. Preoperatively, polymorphonuclear neutrophil chemotaxis was abnormal in the majority of anergic patients, as was the serum albumin concentration. Postoperatively, sepsis, mortality and death due to sepsis were significantly higher in the anergic population, reconfirming the hypothesis that skin test anergy in patients preoperatively is a signal of increased risk for septic complications and death in such patients.
对727例手术患者进行了分析，这些患者在手术前接受了回忆抗原皮肤试验。分析内容包括术前诊断、手术干预、术后脓毒症并发症及死亡情况。与无反应性患者相比，正常皮肤试验反应者年龄相仿，接受的手术操作程度相同。术前，大多数无反应性患者的多形核中性粒细胞趋化性及血清白蛋白浓度均异常。术后，无反应性人群中脓毒症、死亡率及脓毒症所致死亡显著更高，再次证实了术前患者皮肤试验无反应性是此类患者发生脓毒症并发症及死亡风险增加的一个信号这一假说。
