Stallone D D, Stunkard A J, Zweiman B, Wadden T A, Foster G D
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
Clin Diagn Lab Immunol. 1994 Mar;1(2):202-5. doi: 10.1128/cdli.1.2.202-205.1994.
The effect of weight loss on immuno function was evaluated in 14 middle-aged obese women. Cutaneous delayed-type hypersensitivity to five recall antigens was measured before a weight loss of 21 kg and again after weight had been stabilized. Weight loss was associated with a decrease in both number and magnitude of delayed-type hypersensitivity responses. The number of positive skin tests decreased from 3.1 +/- 0.2 to 2.4 +/- 0.3 per subject, and the mean cutaneous induration size decreased by 38%. The decrease in induration size was positively correlated with the decrease in body mass index (r = 0.63), weight (r = 0.59), and fat mass (r = 0.52). These preliminary findings suggest that large weight losses may result in decreased expression of immune function.
在14名中年肥胖女性中评估了体重减轻对免疫功能的影响。在体重减轻21千克之前以及体重稳定后，测量了对五种回忆抗原的皮肤迟发型超敏反应。体重减轻与迟发型超敏反应的数量和强度降低有关。每个受试者的阳性皮肤试验数量从3.1±0.2降至2.4±0.3，皮肤硬结平均大小下降了38%。硬结大小的降低与体重指数的降低(r = 0.63)、体重(r = 0.59)和脂肪量(r = 0.52)呈正相关。这些初步发现表明，大幅体重减轻可能导致免疫功能表达下降。
