Koch M, McPherson T A, Morrish D W
Can Med Assoc J. 1977 Apr 9;116(7):769-71.
Long-term studies on multiple plasma samples of 988 patients with carcinoma of entodermal origin indicate that, especially for patients with colorectal cancer, repeatedly elevated or rising carcinoembryonic antigen (CEA) values are a sign of poor prognosis when found preoperatively, postoperatively or during chemotherapy. Persistently elevated CEA values in postoperative patients apparently free of disease are a useful marker for early detection of recurrence or metastases. Normal CEA values are of little or no prognostic value.
对988例内胚层源性癌症患者的多个血浆样本进行的长期研究表明,特别是对于结直肠癌患者,术前、术后或化疗期间反复出现癌胚抗原(CEA)值升高或上升是预后不良的迹象。术后看似无疾病的患者中CEA值持续升高是早期发现复发或转移的有用标志物。正常的CEA值几乎没有或没有预后价值。