甲氨蝶呤对结缔组织病相关纤维化肺泡炎的反应。

Scott D G, Bacon P A

Thorax. 1980 Oct;35(10):725-31. doi: 10.1136/thx.35.10.725.

Methotrexate by intermittent intramuscular injection was used to treat three patients with fibrosing alveolitis complicating connective tissue diseases. All three patients had improvement of symptoms, two had radiological improvement, and one had significant improvement of pulmonary function. Two patients whose pulmonary symptoms, function, and chest radiographs had deteriorated on penicillamine improved when treated with methotrexate. Methotrexate may be a useful treatment for fibrosing alveolitis complicating connective tissue diseases.

采用间断肌肉注射甲氨蝶呤治疗3例合并结缔组织病的肺纤维化患者。所有3例患者症状均有改善，2例影像学表现改善，1例肺功能显著改善。2例因青霉胺治疗导致肺部症状、功能及胸部X线片恶化的患者，改用甲氨蝶呤治疗后病情改善。甲氨蝶呤可能是治疗合并结缔组织病的肺纤维化的有效药物。