个体对香烟烟雾细胞毒性反应的差异。
Variation in individual responses to the cytotoxicity of cigarette smoke.
作者信息
Hopkin J M, Steel C M
出版信息
Thorax. 1980 Oct;35(10):751-3. doi: 10.1136/thx.35.10.751.
Abstract
There is increasing evidence that elastase may mediate pulmonary damage in emphysema and also that the release of intracellular elastase by cigarette smoke is necessarily associated with cell death. We report consistent and significant variation in response of lymphocytes from different individuals to the cytotoxic effect of cigarette smoke condensate in vitro. This variation which occurred at levels of cigarette smoke likely to be encountered in vivo and which was independent of the age, sex, or smoking habits of the subjects, may be relevant in determining the risk of developing emphysema amongst smokers.
摘要
越来越多的证据表明，弹性蛋白酶可能在肺气肿中介导肺损伤，而且香烟烟雾引起的细胞内弹性蛋白酶释放必然与细胞死亡有关。我们报告了不同个体的淋巴细胞对香烟烟雾浓缩物体外细胞毒性作用的反应存在一致且显著的差异。这种差异发生在体内可能遇到的香烟烟雾水平，并且与受试者的年龄、性别或吸烟习惯无关，可能在确定吸烟者患肺气肿的风险方面具有相关性。
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