Zuccato E, Marcucci F, Mussini E
Toxicol Lett. 1980 Mar;5(3-4):213-17. doi: 10.1016/0378-4274(80)90062-4.
1, 5 and 10 mg/kg vinyl chloride monomer (VCM) in aqueous solution were injected i.v. into male rats with cannulated tracheas. Respiratory activity was regulated to permit investigation of the effect of modifying pulmonary ventilation on VCM excretion in blood and expired air assayed at different intervals for VCM. VCM excretion rate was found to be directly proportionate to pulmonary ventilation. When respiration was stopped for 1 min after VCM injection, there was no decrease in blood BCM, the main route of elimination of i.v. injected VCM thus being pulmonary.
将1、5和10毫克/千克氯乙烯单体（VCM）的水溶液静脉注射到有插管气管的雄性大鼠体内。调节呼吸活动，以便研究改变肺通气对不同时间间隔测定的血液和呼出气体中VCM排泄的影响。发现VCM排泄率与肺通气直接成比例。在注射VCM后停止呼吸1分钟，血液中VCM（静脉注射VCM的主要消除途径）没有减少，因此其主要消除途径是肺部。
