氯乙烯的代谢研究。
Studies on the metabolism of vinyl chloride.
作者信息
Antweiler H
出版信息
Environ Health Perspect. 1976 Oct;17:217-9. doi: 10.1289/ehp.7617217.
Abstract
Vinyl chloride (VCM) is not carcinogenic by itself, it is bioactivated to the highly reactive alkylating oxirane chloroethylene oxide. Further metabolism, apparently, leads via an interaction of the primary alkylating metabolites with glutathion to S-(2-carboxy-methyl)-cysteine and thiodiacetic acid which are eliminated with the urine. Up to now, it has not been ascertained whether the oxirane alone is the essential carcinogenic factor or whether other metabolites are also involved in carcinogenicity. Likewise, it is still unknown whether the metabolites excreted in the urine might be used as biological criteria for exposure to VCM, because these metabolites probably can originate from a series of substances other than VCM. This problem could stimulate investigations on the possible carcinogenic activity of these substances.
摘要
氯乙烯（VCM）本身并无致癌性，它可被生物活化成高反应性的烷基化环氧氯乙烷。显然，进一步的代谢过程是通过初级烷基化代谢产物与谷胱甘肽相互作用，生成S-(2-羧甲基)-半胱氨酸和硫代二乙酸，这些物质会随尿液排出。到目前为止，尚未确定单独的环氧乙烷是否为主要致癌因素，或者其他代谢产物是否也参与致癌作用。同样，尿液中排出的代谢产物是否可作为接触VCM的生物学指标仍不清楚，因为这些代谢产物可能源自一系列除VCM之外的物质。这个问题可能会激发对这些物质潜在致癌活性的研究。
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