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[高密度脂蛋白亚类的初步分离及其组成特征]

[Preparatory isolation of subclasses of high density lipoproteins and features of their composition].

作者信息

Shcherbakova I A, Perova N V, Karmanskiĭ I M, Torkhovskaia T I

出版信息

Vopr Med Khim. 1981 Jan-Feb;27(1):102-8.

PMID:7467196
Abstract

An improved procedure is described for separation of high density lipoproteins /HDLP/ into subfractions using narrow salt gradient with optimal concentration for each subfraction. Lipid and protein composition of the HDLP subfractions obtained was studied. Analysis of the subfractions in persons with various concentration of alpha-cholesterol enabled to conclude that concentration of the HDLP2 was preferably increased in hyperalphalipoproteinemia; in this case protein and lipid compositions of both lipoprotein subfractions were not altered as compared with those in normal alphalipoproteinemia.

摘要

本文描述了一种改进的方法,该方法使用对每个亚组分具有最佳浓度的窄盐梯度将高密度脂蛋白(HDLP)分离成亚组分。对所得HDLP亚组分的脂质和蛋白质组成进行了研究。对不同α-胆固醇浓度人群的亚组分分析表明,在高α脂蛋白血症中,HDLP2的浓度最好升高;在这种情况下,与正常α脂蛋白血症相比,两种脂蛋白亚组分的蛋白质和脂质组成没有改变。

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