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[苯乙双胍和米斯克隆对乳腺癌患者迟发型超敏反应的影响]

[Effect of fenformin and miscleron on the delayed hypersensitivity reaction in breast cancer patients].

作者信息

Bershteĭn L M, Buslaeva V P, Kondrat'ev V B, Ostroumova M N, Semiglazov V F

出版信息

Vopr Onkol. 1980;26(12):28-31.

PMID:7467216
Abstract

Some preliminary results of using phenformin and miscleron in 17 breast cancer patients, previously radically operated upon, have been assessed as being characterized by metabolic disturbances associated with the reduced cell immunity level. The treatment of patients during 15--7 months was shown to result both in the correction of endocrine-metabolic disorders and stimulation of delayed hypersensitivity response, determined by skin tests with dinitro-chlorbenzene, tuberculin and Candida. The necessity to liquidate metabolic metabolic immunodepression with the aim of prophylaxis and treatment of the tuumor process is discussed. Some other routes of metabolic immunotherapy in addition to using phenformin and miscleron are considered. It seems rational to study the effect of a continuous administration of such kind of drugs on the results of treatment of oncological patients.

摘要

对17例曾接受过根治性手术的乳腺癌患者使用苯乙双胍和米斯克隆的一些初步结果进行了评估,结果表明其特征为与细胞免疫水平降低相关的代谢紊乱。对患者进行15至7个月的治疗后发现,这既能纠正内分泌代谢紊乱,又能刺激由二硝基氯苯、结核菌素和念珠菌皮肤试验所确定的迟发型超敏反应。讨论了为预防和治疗肿瘤过程而消除代谢性免疫抑制的必要性。除了使用苯乙双胍和米斯克隆之外,还考虑了代谢免疫疗法的其他一些途径。研究持续使用这类药物对肿瘤患者治疗结果的影响似乎是合理的。

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