Peiker G, Müller B, Ihn W, Nöschel H
Zentralbl Gynakol. 1980;102(10):537-41.
Each of nine nursing mothers received one single intramuscular injection of 50 mg pethidine (Dolcontral), between the third and eighth days from childbirth. The highest pethidine concentration, 0.526 mumol/l or 0.13 microgrms/ml, was recorded from breast milk, two hours from application. After 24 hours, the concentration had dropped to 0.081 mumol/l or 0.02 microgram/ml. - The milk-serum quotient was in excess of 1.0. A correlation was found to exist between pethidine concentrations in the serum, on the one hand, and those in mother's milk, on the other. - One single application of Dolcontral is not expected to be of harmful effect on the newborn.
九名哺乳期母亲在分娩后的第三天至第八天期间，每人接受了一次50毫克哌替啶（度冷丁）的肌肉注射。用药两小时后，母乳中记录到最高哌替啶浓度为0.526微摩尔/升或0.13微克/毫升。24小时后，浓度降至0.081微摩尔/升或0.02微克/毫升。——乳清商超过1.0。研究发现，血清中的哌替啶浓度与母乳中的哌替啶浓度之间存在相关性。——预计单次使用度冷丁对新生儿不会产生有害影响。
