Bajnóczky K, Meggyessy V, Méhes K
Acta Paediatr Acad Sci Hung. 1980;21(2-3):139-43.
Cytogenetic investigations were carried out before and after steroid treatment in 12 infants who had received 1.5 mg/kg of prednisolone daily for 4 days. No significant change in the frequency of structural aberrations and sister chromatid exchange was found. The number of satellite associations increased, which was attributed to the cell cycle delaying effect of prednisolone. A conspicuous alteration in the sequence of centromere separation was observed, as the originally non-random distribution of early divided centromeres tended to near randomness. The question is raised whether the phenomenon may be indicative of mutagenicity.
对12名婴儿在接受每天1.5毫克/千克泼尼松龙治疗4天的类固醇治疗前后进行了细胞遗传学研究。未发现结构畸变和姐妹染色单体交换频率有显著变化。卫星联合的数量增加，这归因于泼尼松龙的细胞周期延迟效应。观察到着丝粒分离顺序有明显改变，因为早期分裂着丝粒原本的非随机分布趋于接近随机。提出了该现象是否可能指示致突变性的问题。
