Kjellman B, Tollig H, Wettrell G
Allergy. 1980 Oct;35(7):605-10. doi: 10.1111/j.1398-9995.1980.tb01811.x.
In this study the effects of nebulized racemic epinephrine (Micronephrine) were investigated in children with asthma. The drug was inhaled by a compressor nebulizer with a plastic mask. In the first part of the study it is shown that nebulized Micronephrine has a dose-dependent bronchodilatory effect. In the second part the effect is compared with that of nebulized salbutamol in 10 children (7-16 years of age) with bronchial asthma. The highest dose used in the dose-response trials (=0.9 mg Micronephrine/kg body-weight) was compared with 0.15 mg salbutamol/kg body-weight, which is the dose commonly used in Sweden. There was no significant difference between the drugs as regards increase of forced expiratory volume in 1 sec or duration of the increase. There was a small but significant increase in systolic blood pressure, measured 5 min after the inhalation of Micronephrine but no significant change in diastolic pressure or heart rate. Four children complained of temporary sore throat after the inhalation.
在本研究中，对雾化消旋肾上腺素（米克罗肾上腺素）治疗哮喘患儿的效果进行了调查。药物通过带有塑料面罩的压缩雾化器吸入。在研究的第一部分表明，雾化米克罗肾上腺素具有剂量依赖性支气管扩张作用。在第二部分中，将其效果与10名（7 - 16岁）支气管哮喘患儿雾化沙丁胺醇的效果进行了比较。剂量反应试验中使用的最高剂量（= 0.9毫克米克罗肾上腺素/千克体重）与瑞典常用剂量0.15毫克沙丁胺醇/千克体重进行了比较。在1秒用力呼气量增加或增加持续时间方面，两种药物之间没有显著差异。吸入米克罗肾上腺素5分钟后测量的收缩压有小幅但显著的升高，但舒张压或心率没有显著变化。4名儿童在吸入后抱怨有短暂的喉咙痛。
