Eriksson N E, Haglind K, Hidinger K G
Allergy. 1980 Oct;35(7):617-22. doi: 10.1111/j.1398-9995.1980.tb01813.x.
In a double-blind, cross-over, 2-day study 32 adult asthmatic patients compared the bronchodilating effect of 0.5 mg terbutaline sulphate aerosol, administered via a 10 cm tube extension attached to the actuator of a pressurized aerosol, with that of 0.2 mg salbutamol sulphate, administered by a conventional pressurized aerosol. New instructions for the inhalation technique were given for the terbutaline aerosol, dividing the actuation of the aerosol and the slow inhalation into two steps. The salbutamol aerosol was to be taken according to the instructions enclosed, i.e. coordinating the actuation of the aerosol and the inhalation. The improvement in peak expiratory flow rate (PEFR) values was similar for the two treatments. Subjective assessments by the patients showed no differences between the two regimens. As the effect seems to be equal, an aerosol actuator furnished with a tube extension, with no strict demands of synchronizing the actuation of the aerosol and the inhalation, could be a suitable alternative treatment in patients who find self-administration with conventional asthma aerosols difficult.
在一项为期2天的双盲、交叉研究中，32名成年哮喘患者比较了通过连接在加压气雾剂促动器上的10厘米延长管给予的0.5毫克硫酸特布他林气雾剂与通过传统加压气雾剂给予的0.2毫克硫酸沙丁胺醇的支气管扩张作用。针对特布他林气雾剂给出了新的吸入技术说明，将气雾剂的启动和缓慢吸入分为两个步骤。沙丁胺醇气雾剂应按照随附说明使用，即协调气雾剂的启动和吸入。两种治疗方法的呼气峰值流速（PEFR）值改善情况相似。患者的主观评估显示两种治疗方案之间没有差异。由于效果似乎相同，配备延长管且对气雾剂启动和吸入同步无严格要求的气雾剂促动器，对于那些难以使用传统哮喘气雾剂进行自我给药的患者而言，可能是一种合适的替代治疗方法。
