Tukiainen H, Terho E O
Eur J Clin Pharmacol. 1985;27(6):645-7. doi: 10.1007/BF00547042.
The short-term bronchodilator effects of dry salbutamol powder and a pressurized salbutamol aerosol were compared in 22 patients with severe asthma, on 3 consecutive mornings, in a double-dummy cross-over study. Only patients with peak expiratory flow (PEF) rate lower than 250 l/min, were recruited. PEF measurement was employed to assess changes in ventilatory function induced by inhalation of the drugs. No significant difference was found between the PEF changes induced by the dry salbutamol powder (400 micrograms) and the pressurized aerosol (200 micrograms). Both forms of the drug produced a significant rise in mean PEF values. The study shows that even in asthmatic patients with poor ventilation, a dry powder inhaler and pressurized aerosol are effective means of drug delivery to the lungs.
在一项双盲交叉研究中，于连续3个早晨对22例重度哮喘患者比较了沙丁胺醇干粉剂与沙丁胺醇压力定量气雾剂的短期支气管扩张作用。仅招募呼气峰值流速（PEF）低于250升/分钟的患者。采用PEF测量来评估吸入药物引起的通气功能变化。沙丁胺醇干粉剂（400微克）和压力定量气雾剂（200微克）引起的PEF变化之间未发现显著差异。两种剂型的药物均使平均PEF值显著升高。该研究表明，即使在通气功能较差的哮喘患者中，干粉吸入器和压力定量气雾剂也是将药物输送至肺部的有效手段。
