Lifshitz-Guinzberg A, Reveles-Delijorge J, Adabache-Ortíz M, López-Barcena J
Arch Invest Med (Mex). 1980;11(3):315-27.
A prospective study was made in 20 patients in the oliguric phase of acute renal failure, 20 patients with prerenal uremia (functional renal failure); 20 patients hospitalized due to different diseases but without renal problems and 20 healthy individuals. In all patients osmolar clearance, free water clearance, urinary sodium and excreted fraction of sodium tests were made. These four parameters could differentiate acute renal failure from prerenal uremia. However differences in urinary sodium concentrations in patients with prerenal uremia was found to be in the borderline for statistical significance and osmolar and free water clearance determinations require strict measurements of urinary volume in a time unit. Excreted sodium fraction requires only simultaneous blood and urine samples for sodium and creatinine quantification.
对20例处于急性肾衰竭少尿期的患者、20例肾前性尿毒症（功能性肾衰竭）患者、20例因不同疾病住院但无肾脏问题的患者以及20名健康个体进行了一项前瞻性研究。对所有患者进行了渗透清除率、自由水清除率、尿钠及钠排泄分数检测。这四个参数可以区分急性肾衰竭和肾前性尿毒症。然而，发现肾前性尿毒症患者的尿钠浓度差异处于统计学意义的临界值，并且渗透清除率和自由水清除率的测定需要严格测量单位时间内的尿量。钠排泄分数仅需要同时采集血样和尿样以进行钠和肌酐定量。
