[肠道过氧化物酶（EC 1.11.1.7）在前列腺素生物合成中可能作用的初步结果]
[Preliminary results on the possible role of intestinal peroxidase (EC 1.11.1.7) in the biosynthesis of prostaglandins].
作者信息
Carlà V, Bovolenta P, Magnani M, Della Corte L, Sgaragli G P
出版信息
Boll Soc Ital Biol Sper. 1980 Dec 30;56(24):2535-8.
PMID:7470299
Abstract
The ability of a partially purified rat ileum peroxidase to synthetize PGE2 and PGF2 alpha from arachidonic acid was researched. The enzyme preparation, when incubated anaerobically with H2O2 and arachidonic acid, produced a compound extractable with ethyl acetate which showed on TLC the same Rf as authentic PGE2. This compound, after elution from the gel, was able to contract the rat strip fundus preparation.
摘要
研究了部分纯化的大鼠回肠过氧化物酶从花生四烯酸合成前列腺素E2（PGE2）和前列腺素F2α（PGF2α）的能力。该酶制剂在与过氧化氢和花生四烯酸厌氧孵育时，产生了一种可用乙酸乙酯萃取的化合物，该化合物在薄层色谱（TLC）上显示出与 authentic PGE2相同的比移值（Rf）。从凝胶上洗脱后，该化合物能够使大鼠胃底条制剂收缩。
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