Handlos V
Biomaterials. 1980 Jul;1(3):149-57. doi: 10.1016/0142-9612(80)90038-1.
The aeration of ethylene-oxide (EO) sterilized medical plastic materials is dealth with mathematically, and subsequently the model found is used for calculation of the EO diffusion coefficient in various plastics with the composition and temperature as variables. Absorption and dissolution of EO in various plastic materials are measured at varying concentrations of EO, temperatures and compositions of plastics. The mathematical model is used to evaluate the EO desorption from medical devices under different physico-chemical conditions as well as in vivo. EO analysis methods are evaluated on the basis of the model and are compared with experimental results.
对环氧乙烷（EO）灭菌的医用塑料材料的通气过程进行了数学处理，随后将所建立的模型用于计算不同塑料中EO的扩散系数，其中组成和温度为变量。在不同的EO浓度、温度和塑料组成条件下，测量了EO在各种塑料材料中的吸收和溶解情况。该数学模型用于评估不同物理化学条件下以及体内医疗器械中EO的解吸情况。基于该模型对EO分析方法进行了评估，并与实验结果进行了比较。
