Peppas N A, Benner R E
Biomaterials. 1980 Jul;1(3):158-62. doi: 10.1016/0142-9612(80)90039-3.
Intracordal polymer solution and/or suspension injection has potential in the swelling of paralysed or partially removed vocal cords to the midline laryngeal position. This technique allows the normally functioning cord to vibrate against the swollen one in order to produce sound. Polymeric systems which may possibly be used for the treatment of vocal cords are presented and analysed with special reference to poly(vinyl alcohol). Aqueous poly(vinyl alcohol) solution in concentrations of 3% to 10% (wt/wt) are gelled by glutaraldehyde. The gelation kinetics are followed and the gelation point, final crosslinking density and structure are determined in terms of the initial molar ratio of crosslinking agent to polymer. The mechanical properties of poly(vinyl alcohol) gels are discussed. Finally a proposed technique for the application of these systems for the treatment of certain vocal cord impairments is presented.
声带内聚合物溶液和/或悬浮液注射在使麻痹或部分切除的声带肿胀至喉中线位置方面具有潜力。该技术使正常功能的声带与肿胀的声带振动以产生声音。本文介绍并分析了可能用于治疗声带的聚合物体系，特别提及了聚乙烯醇。浓度为3%至10%（重量/重量）的聚乙烯醇水溶液通过戊二醛凝胶化。跟踪凝胶化动力学，并根据交联剂与聚合物的初始摩尔比确定凝胶化点、最终交联密度和结构。讨论了聚乙烯醇凝胶的力学性能。最后提出了一种将这些体系应用于治疗某些声带损伤的技术。
