Peppas N A, Merrill E W
J Biomed Mater Res. 1977 May;11(3):423-34. doi: 10.1002/jbm.820110309.
Swollen crosslinked poly(vinyl alcohol) (PVA) networks were developed and tested as potential biomaterials. They were prepared by electron-beam irradiation of aqueous PVA solutions at various temperatures and doses of irradiation. These materials were characterized by low mechanical properties and especially by low elongation at break and ultimate tensile strength. Reinforcement was achieved by a two-stage dehydration-annealing process, introducing crystallites in the polymeric network. Improved mechanical properties were achieved due to the presence of this crystalline PVA phase. Due to their structure, these hydrogels are proposed to be used as biomembranes for selective transport of macromolecules and as biomaterials for synthetic articular cartilage applications. Surface heparinization was accomplished by reacting heparin to the hydroxyl groups of the PVA surface, through covalent acetal bridges.
开发并测试了肿胀交联聚（乙烯醇）（PVA）网络作为潜在的生物材料。它们是通过在不同温度和辐照剂量下对PVA水溶液进行电子束辐照制备的。这些材料的特点是机械性能较低，尤其是断裂伸长率和极限拉伸强度较低。通过两阶段脱水退火工艺实现增强，在聚合物网络中引入微晶。由于这种结晶PVA相的存在，机械性能得到了改善。由于其结构，这些水凝胶被提议用作大分子选择性运输的生物膜以及合成关节软骨应用的生物材料。通过肝素与PVA表面的羟基通过共价缩醛桥反应实现表面肝素化。
