[Dynamics of the concentration of aldosterone, cortisol, and its precursors in the plasma of M. rhesus during long-term restriction of motor activity].

A significant increase in the content of cortisol and its precursors was detected in blood plasma from rhesus monkeys during the first six hours of the motor activity restriction. In the three days following, the peak concentrations of cortisol were accompanied by a fall of 17-hydroxylated precursors to the basal and lower levels. The content of cortisol attained the basal level by the end of the first week of fixation. The levels of cortisol, 11-deoxycortisol, 17-hydroxyprogesterone and 17-hydroxypregnenolone on the 17th day of hypokinesia were 77, 62, 39 and 15%, respectively, as compared with the pre-experimental period. The maximum rise of the aldosterone level in monkey plasma was seen on the 2--3d day followed by a gradual decrease in its concentrations over the entire experimental period. It is suggested that the reduced blood content of steroids during the restriction of motor activity is related to the adaptation of pituitary-adrenal system function to the decreased environmental requirements.