Tavadian D S, Goncharov N P
Biull Eksp Biol Med. 1980 Dec;90(12):663-6.
A significant increase in the content of cortisol and its precursors was detected in blood plasma from rhesus monkeys during the first six hours of the motor activity restriction. In the three days following, the peak concentrations of cortisol were accompanied by a fall of 17-hydroxylated precursors to the basal and lower levels. The content of cortisol attained the basal level by the end of the first week of fixation. The levels of cortisol, 11-deoxycortisol, 17-hydroxyprogesterone and 17-hydroxypregnenolone on the 17th day of hypokinesia were 77, 62, 39 and 15%, respectively, as compared with the pre-experimental period. The maximum rise of the aldosterone level in monkey plasma was seen on the 2--3d day followed by a gradual decrease in its concentrations over the entire experimental period. It is suggested that the reduced blood content of steroids during the restriction of motor activity is related to the adaptation of pituitary-adrenal system function to the decreased environmental requirements.
在恒河猴运动活动受限的头六个小时内，检测到其血浆中皮质醇及其前体的含量显著增加。在随后的三天里，皮质醇的峰值浓度伴随着17-羟化前体降至基础水平及更低水平。到固定第一周结束时，皮质醇含量达到基础水平。与实验前时期相比，运动减退第17天时皮质醇、11-脱氧皮质醇、17-羟孕酮和17-羟孕烯醇酮的水平分别为77%、62%、39%和15%。猴血浆中醛固酮水平在第2 - 3天出现最大升高，随后在整个实验期间其浓度逐渐降低。有人认为，运动活动受限期间类固醇血液含量的降低与垂体-肾上腺系统功能适应环境需求降低有关。
