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[通过磁泳疗法预防豚鼠实验性变应性脑脊髓炎]

[Prevention of experimental allergic encephalomyelitis in guinea pigs by treatment with magnetophores].

作者信息

Zhitnukhin Iu L, Zatepiakin Iu S, Karasik O A

出版信息

Biull Eksp Biol Med. 1980 Dec;90(12):713-5.

PMID:7470609
Abstract

Subcutaneous application of magnetophores with a field intensity of 210 ersted prevented the development of experimental allergic encephalomyelitis (EAE) in guinea-pigs. The magnetophores appeared efficacious both at the beginning of the induction period and in the second half of the latent period, i.e. within the first two weeks after injection of encephalitogenic suspension. Application of magnetophores after the appearance of the neurological signs of EAE was ineffective. Magnetophores did not affect cellular or humoral response in animals. It may be assumed that the effect of magnetophores is related to the increased resistance of nerve cells to the immunopathological action of the immune response factors, a topic for further studies.

摘要

对豚鼠皮下施加场强为210奥斯特的磁体,可预防实验性变应性脑脊髓炎(EAE)的发生。磁体在诱导期开始时和潜伏期后半段均显示出效果,即在注射致脑炎悬浮液后的前两周内。在EAE出现神经症状后施加磁体则无效。磁体对动物的细胞或体液反应没有影响。可以推测,磁体的作用可能与神经细胞对免疫反应因子免疫病理作用的抵抗力增强有关,这是一个有待进一步研究的课题。

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