Huang E M, Detwiler T C
Blood. 1981 Apr;57(4):685-91.
Platelets are activated by many different agonists that act synergistically. Since there is a characteristic pattern of responses to each agonist, and since there is a clear distinction between weak and strong agonists, understanding the nature of the synergism and its physiologic significance requires characterization of the pattern of responses to the synergistic action of the various agonists. Shape change, aggregation, and secretion of ATP by human platelets in citrated plasma were analyzed after activation by ADP, epinephrine, arachidonic acid, gamma-thrombin, or collagen, either singly or in pairs. The patterns of responses were characteristic of the agonist in higher concentration relative to its threshold concentration; if neither was clearly higher, the pattern of responses was intermediate between the responses characteristic of each agonist. No combination of weak agonists had the characteristics of a strong agonist. These results help define the extent to which platelet responses can be attributed to the synergistic actions of weak agonists.
血小板可被多种不同的激动剂协同激活。由于对每种激动剂都有特定的反应模式，而且弱激动剂和强激动剂之间有明显区别，因此要理解协同作用的本质及其生理意义，就需要对各种激动剂协同作用的反应模式进行表征。在枸橼酸盐血浆中，分别或成对地用二磷酸腺苷（ADP）、肾上腺素、花生四烯酸、γ-凝血酶或胶原激活人血小板后，分析了血小板的形态变化、聚集及ATP分泌情况。相对于阈值浓度，较高浓度激动剂的反应模式具有该激动剂的特征；如果两者浓度都没有明显更高，则反应模式介于每种激动剂的特征反应之间。弱激动剂的任何组合都不具有强激动剂的特征。这些结果有助于确定血小板反应可归因于弱激动剂协同作用的程度。
